Which schedule of controlled substances has the lowest potential for abuse?

• A. Schedule I
• B. Schedule II
• C. Schedule IV
• D. Schedule V

Answer: (D)

The schedule of controlled substances that has the lowest potential for abuse is Schedule V. Substances classified under Schedule V are those that have accepted medical uses in the United States and exhibit a lower likelihood of causing physical or psychological dependence compared to higher schedules. This makes them more accessible for patients needing treatment for conditions such as cough suppression or diarrhea, often leading to fewer regulatory restrictions than those placed on higher-schedule medications.

For instance, drugs in this category, such as certain formulations of cough preparations or medications containing very low doses of codeine, are generally considered safe with minimal risk of abuse when used as directed. This is in stark contrast to substances in higher schedules, which are typically associated with more stringent regulations due to a higher potential for abuse and dependence.